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Eye throws
Enter X, Z and Yaw from F3 for each throw.
Result
Use at least two throws to calculate the intersection.
Waiting for throws
Throw the Eye of Ender, look along its flight path, then write down X, Z and Yaw.
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Which F3 angle should I use?
Use Yaw only. Pitch is not needed.
Open F3, throw the Eye of Ender, look exactly along the flight direction and write down the horizontal rotation angle: Yaw.
Minecraft 1.21.11+: if Yaw is hidden, enable rotation/Yaw in the F3 debug settings.